Bladder cancer


Diagnosing bladder cancer

Page last updated: May 2024

Expert content reviewers:


If your doctor suspects you have bladder cancer, they will examine you and arrange tests. The tests you have may include:

  • general tests to check your overall health and body function
  • tests to find cancer
  • further tests to see if the cancer has spread (metastasised).

Some tests may be repeated during and after treatment to see how the treatment is working. If you feel anxious waiting for test results, it may help to talk to a friend or family member, or call Cancer Council 13 11 20.

General tests

As the bladder is close to the rectum and vagina, your doctor may do an internal examination by sliding a gloved finger into the rectum or vagina to feel for anything unusual.

Some people find this test embarrassing or uncomfortable, but it takes only a few seconds. Sometimes you won’t need an internal examination until after bladder cancer has been diagnosed.

Your doctor may take blood samples to check your overall health. You will also be asked for a urine sample, which will be checked for blood and bacteria (urinalysis).

If you have blood in your urine, you may need to collect urine samples over three days. These samples will be checked for cancer cells (urine cytology).

Tests to find cancer in the bladder

The main test to look for bladder cancer is a cystoscopy, which lets your doctor look closely at the bladder lining (urothelium).

Other tests can give your doctors more information about the cancer. These may include an ultrasound before the cystoscopy, a tissue sample (biopsy) taken during a cystoscopy, and a CT or MRI scan.

Before having scans, tell the doctor if you have any allergies or have had a reaction to contrast (dye) during previous scans. You should also let them know if you have diabetes or kidney disease or are pregnant or breastfeeding.

Ultrasound

CT scan

MRI scan

Cystoscopy

Transurethral resection of bladder tumour

“My diagnosis was made after the biopsy. I felt relieved to finally have a label for my illness.” Dee

Further tests

You might also need other imaging tests such as a radioisotope bone scan, x-rays or a PET–CT scan to show if and how far the cancer has spread.

Radioisotope bone scan

X-rays

PET–CT scan

 

Staging bladder cancer

The tests above help show whether you have bladder cancer, how far the cancer has grown into the layers of the bladder, and whether there are any signs of cancer outside the bladder.

This is called staging. Your doctor may describe the cancer as:

  • Superficial bladder cancer – this is also called non-muscle-invasive bladder cancer or NMIBC. The cancer cells are found only in the inner lining of the bladder (urothelium) or the next layer of tissue (lamina propria) and haven’t grown into the deeper layers of the bladder wall.
  • Muscle-invasive bladder cancer (MIBC) – the cancer has spread beyond the urothelium and lamina propria into the layer of muscle (muscularis propria), or sometimes through the bladder wall into the surrounding fatty tissue. MIBC can also sometimes spread to lymph nodes close to the bladder.
  • Advanced bladder cancer – the cancer has spread (metastasised) outside of the bladder into distant lymph nodes or other organs of the body.

The most common staging system for bladder cancer is the TNM (tumour-nodes-metastasis) system.

In this system, letters and numbers are used to describe the cancer, with higher numbers indicating larger size or spread. 

Some doctors put the TNM scores together to produce an overall stage, from stage 1 (earliest stage) to stage 4 (most advanced).

Grade and risk category

The biopsy and/or TURBT results will show the grade of the cancer. This is a score that describes how quickly a cancer might grow.

Knowing the grade helps your urologist predict how likely the cancer is to come back (recur) and if you will need further treatment after surgery.

The grade may be described as:

  • Low grade – the cancer cells look similar to normal bladder cells and are usually slow-growing. They are less likely to invade and spread.
  • High grade – the cancer cells look very abnormal and grow quickly. They are more likely to spread both into the bladder muscle and outside the bladder.

In superficial bladder cancers, the grade may be low or high, while almost all muscle-invasive cancers are high grade.

Carcinoma in situ (stage Tis in the TNM system) is a high-grade tumour that needs to be treated quickly to prevent it invading the muscle layer.

Based on the stage, grade and other features, a superficial bladder cancer will also be classified as having a lower or higher risk of returning after treatment or spreading into the muscle layer.

Knowing the risk category will help your doctors work out which treatments to recommend.

Get support

A cancer diagnosis can affect every aspect of your life. You will probably experience a range of emotions – fear, sadness, anxiety, anger and frustration are all common reactions. Cancer also often creates practical and financial issues.

To find good sources of support and information, you can talk to the social worker or nurse at your hospital or treatment centre, or get in touch with Cancer Council 13 11 20.

Contact cancer support

Prognosis

Prognosis means the expected outcome of a disease. You may wish to discuss your prognosis with your doctor, but it is not possible for anyone to predict the exact course of the disease.

In general, the earlier bladder cancer is diagnosed, the better the outcome. To work out your prognosis, your doctor will consider:

  • your test results
  • the type of bladder cancer
  • the stage, grade and risk category
  • how well you respond to treatment
  • other factors such as your age, fitness and medical history.

Understanding Bladder Cancer

Download our Understanding Bladder Cancer booklet to learn more

Download now  Order for free

Talking bubbles icon

Questions about cancer?

Call or email our experienced cancer nurses for information and support.

Contact a cancer nurse