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Prostate cancer


Managing and treating prostate cancer

Page last updated: June 2024

The information on this webpage was adapted from Understanding Prostate Cancer - A guide for people with cancer, their families and friends (2024 edition). This webpage was last updated in June 2024.

Expert content reviewers:

This information was developed based on Australian and international clinical practice guidelines, and with the help of a range of health professionals and people affected by prostate cancer:

  • Prof Declan Murphy, Consultant Urologist, Director – Genitourinary Oncology, Peter MacCallum Cancer Centre and The University of Melbourne, VIC
  • Alan Barlee, Consumer
  • Dr Patrick Bowden, Radiation Oncologist, Epworth Hospital, Richmond, VIC
  • Bob Carnaby, Consumer
  • Dr Megan Crumbaker, Medical Oncologist, St Vincent’s Hospital Sydney, NSW
  • Henry McGregor, Health Physiotherapist, Adelaide Men’s Health Physio, SA
  • Jessica Medd, Senior Clinical Psychologist, Department of Urology, Concord Repatriation General Hospital and Headway Health, NSW
  • Dr Gary Morrison, Shine a Light (LGBTQIA+ Cancer Support Group)
  • Caitriona Nienaber, 13 11 20 Consultant, Cancer Council WA;
  • Graham Rees, Consumer
  • Kerry Santoro, Prostate Cancer Specialist Nurse Consultant, Southern Adelaide Local Health Network, SA
  • Prof Phillip Stricker, Chairman, Department of Urology, St Vincent’s Private Hospital, NSW
  • Dr Sylvia van Dyk, Brachytherapy Lead, Peter MacCallum Cancer Centre, VIC.


There are different options for managing and treating prostate cancer, and more than one treatment may be suitable for you. Your specialists will usually let you know your options.

You may want to ask your treating doctor what other options are available to you. For example, if surgery is suggested you could ask if radiation therapy is also a suitable option.

The treatment recommended by your doctors will depend on the stage and grade of the prostate cancer as well as your general health, age and preferences.

Monitoring prostate cancer

Choosing active surveillance or watchful waiting avoids treatment side effects, but you may feel anxious about not having active treatment.

Talk to your doctors about ways to manage any worries or call 13 11 20 cancer support.

Options by stage

Localised (early)

  • active surveillance
  • surgery and/or radiation therapy
  • watchful waiting

Locally advanced

  • surgery and/or radiation therapy
  • androgen deprivation therapy (ADT) may also be suggested
  • watchful waiting

Advanced (metastatic)

  • usually androgen deprivation therapy (ADT)
  • additional hormone therapy, newer drug therapy or targeted therapy is often combined with ADT
  • sometimes chemotherapy or radiation therapy
  • watchful waiting may be an option
  • newer treatments as part of a clinical trial.

Active surveillance

This is a way of closely monitoring low-risk prostate cancer that isn’t causing symptoms. The aim is to avoid treatment that's not yet needed, while watching for changes that mean treatment should start.

Active surveillance is usually suggested for prostate cancers with a PSA level under 10 ng/mL, stage T1–2, and Gleason 6 or less (Grade Group 1).

It may also be suggested for certain cancers with a PSA level between 10 and 20, and some Grade Group 2 cancers.

About 80% of Australians with low-risk prostate cancer choose active surveillance. It involves:

  • PSA tests every 3–6 months
  • a digital rectal examination
  • mpMRI scans and biopsies as advised by your urologist.

If results show the cancer is growing faster or more aggressively, your specialist may suggest starting active treatment.

Watchful waiting

Watchful waiting may be suggested if you are older and the cancer is unlikely to cause a problem in your lifetime.

It may be an alternative to active treatment if the cancer is advanced at diagnosis, or if other health problems that would make it hard to handle surgery or radiation therapy.

The aim of watchful waiting is to maintain quality of life rather than to treat the cancer.

If the cancer spreads or causes symptoms, you will have treatment to relieve symptoms or slow the growth of the cancer, rather than to cure it.

Watchful waiting usually involves fewer tests than active surveillance. You will have regular PSA tests and you probably won’t have a biopsy.  Your doctor may suggest an MRI if your PSA is rising and of concern.

“I’d recommend that anyone join a group as early as possible after diagnosis.” Tony Explore prostate cancer support groups

Surgery

For many people, surgery will be a suggested treatment option. It is worth discussing with your urologist or treating doctor whether there are other options, such as radiation therapy, available to you.

The main surgery for localised and locally advanced prostate cancer is a radical prostatectomy. It removes all the prostate, part of the urethra and the seminal vesicles.

The urethra is rejoined to the bladder, and the vas deferens (that carry sperm from the testicles to the penis) will be sealed.

Some people have a nerve-sparing radical prostatectomy, to avoid damaging the nerves that control erections. This is only for lower-grade cancers where the cancer isn’t close to these nerves, and it works best for those who had strong erections before.

Problems with erections are common even with nerve-sparing surgery. Cancer cells can spread from the prostate to nearby lymph nodes. For intermediate-risk or high-risk prostate cancer, nearby lymph nodes may also be removed.

How the surgery is done

Different surgical methods may be used to remove the prostate:

  • open radical prostatectomy – usually done through one long cut in the lower abdomen (belly)
  • laparoscopic radical prostatectomy (keyhole surgery) – small surgical instruments and a camera are inserted through several small cuts in the abdomen. The surgeon performs the procedure by moving the instruments using the image on the screen as a guide 
  • robotic-assisted radical prostatectomy – laparoscopic surgery performed with help from a robotic system. The surgeon uses a 3D picture and control panel to move robotic arms holding instruments.

Talk to your surgeon about the methods and other treatment options available to you, and the advantages and disadvantages of each option. There may be extra costs involved for some procedures and they are not all available at every hospital.

You may want to consider getting a second opinion. The surgeon’s experience and skill are more important than the type of surgery offered.

Compared to open surgery, both standard laparoscopic surgery and robotic-assisted surgery usually mean a shorter hospital stay, less bleeding, a smaller scar and a faster recovery.

Current evidence suggests that the different approaches have a similar risk of side effects. Take the time you need to make the right decision for you.

What to expect after surgery

  • Recovery time – whichever surgical method is used, a radical prostatectomy is major surgery and you will need time to recover. You can expect to return to your usual activities within about six weeks. Usually you can start driving again in a couple of weeks, but heavy lifting should be avoided for six weeks.
  • Pain and discomfort – it’s common to have pain after the surgery, so you may need pain relief for a few days.
  • Having a catheter – you will have a thin, flexible tube (catheter) in your bladder to drain your urine into a bag. The catheter will be removed after 1–2 weeks once the wound has healed.

Side effects of prostate cancer surgery

You may experience some or all of the following side effects:

  • Nerve damage – the nerves needed for erections and the muscle that controls the flow of urine (sphincter) are both close to the prostate. It may be very difficult to avoid these during surgery, and any damage can cause problems with erections and bladder control. Sometimes the nerves will need to be removed to try to ensure all cancer is removed.
  • Loss of bladder control – you can expect to have some light dribbling or trouble controlling your bladder (urinary incontinence or urinary leakage) for some weeks to months, which can be managed by using continence pads. Bladder control usually improves in a few weeks and will continue to improve for up to a year after the surgery. In the long term, some people will continue to have some light dribbling. Some people may consider having an operation to fix urinary incontinence. In rare cases, people have no control over their bladder.
  • Changes in erections (erectile dysfunction or impotence) – problems getting and keeping erections after prostate surgery are common. Erections may improve over months to a few years. It’s more likely you won’t get strong erections again if they were already difficult before the operation. 
  • Changes in ejaculation – during a radical prostatectomy, the tubes from the testicles (vas deferens) are sealed and the prostate and seminal vesicles are removed. This means semen is no longer ejaculated during orgasm (a dry orgasm). Your orgasm may feel different – it may be uncomfortable or, rarely, painful. A small amount of urine may leak during orgasm (which isn't harmful to your partner).
  • Infertility – a radical prostatectomy will cause infertility, so you won't be able to conceive a child without medical assistance. If you wish to have children, talk to your doctor before treatment about sperm banking or other options.
  • Changes in penis size – you may notice that your penis gradually becomes a little shorter after surgery. Talk to your doctor about whether vacuum erection devices and prescription medicines may help. A change to the size of your penis can be difficult to deal with, see side effects for ways to get support.

 

Your guide to best cancer care

A lot can happen in a hurry when you’re diagnosed with cancer. The  guide to best cancer care for prostate cancer can help you make sense of what should happen.

It will help you with what questions to ask your health professionals to make sure you receive the best care at every step.

Read the guide

Radiation therapy

Radiation therapy (also known as radiotherapy) uses a controlled dose of radiation to kill or damage cancer cells so they cannot grow, multiply or spread. Radiation therapy may be used: 

  • for localised or locally advanced prostate cancer – it has similar rates of success to surgery in controlling prostate cancer that has spread to the lymph nodes
  • if you are not well enough for surgery or are older
  • after a radical prostatectomy for locally advanced disease, if there are signs of cancer left behind or the cancer has returned where the prostate used to be
  • for prostate cancer that has spread to other parts of the body
  • for intermediate and high-risk prostate cancer, it is often combined with androgen deprivation therapy (ADT).

There are two main ways of delivering radiation therapy – from outside the body (external beam radiation therapy) or inside the body (brachytherapy). You may have one of these or a combination of both.

For more information about how radiation therapy works, visit targetingcancer.com.au.

External beam radiation therapy (EBRT)

In EBRT, a machine precisely directs radiation beams to the prostate. Each treatment session takes about 15 minutes. You will lie on the treatment table under the radiation machine.

The machine doesn’t touch you but may rotate around you. You can’t see or feel the radiation.

There are different types of EBRT. Your radiation oncologist will talk to you about the most suitable type for your situation.

Usually, EBRT for prostate cancer is given Monday to Friday for 4–9 weeks. Some newer forms of EBRT are given in 5–7 treatments over two weeks.

EBRT does not make you radioactive and there is no danger to people near you. Most people feel well enough to work and do their normal activities, though fatigue may increase as your treatment continues.

Internal radiation therapy (brachytherapy)

Brachytherapy is a type of targeted internal radiation therapy where the radiation source is placed inside the body near the prostate.

Giving doses of radiation directly into the prostate can lower the amount of unwanted radiation going into areas such as the rectum and bladder.

There are two different types of brachytherapy: permanent and temporary. If you already have significant urinary symptoms or a large prostate, brachytherapy may not be suitable

Safety precautions after brachytherapy

If you have permanent brachytherapy your body may give off some radiation for a period of time. The levels will gradually fall over a number of months. This radiation only travels a short distance, which means there is little radiation outside your body.

You will still need to take care spending time in close contact with pregnant women and young children for a few weeks or months after the seeds (see next page) are inserted. Your treatment team will explain the precautions to you.

You should use a condom during sex (intercourse and oral) for this precaution time in case a seed comes out (this is rare).

If you have temporary brachytherapy, you will not be radioactive once the wires are removed after treatment, and there is no risk to other people and no special precautions are needed during sex.

Side effects of radiation therapy

The side effects you experience will vary depending on the type and dose of radiation, and the areas treated. Most side effects are temporary and tend to improve gradually in the weeks after treatment ends. Short-term side effects may include:

  • fatigue
  • urinary problems
  • bowel changes, and
  • ejaculation changes.

Some side effects may not show up until many months or years after treatment. These are known as late effects and may include:

  • infertility
  • urinary problems
  • bowel changes, and
  • erection problems.

To help prevent bowel side effects, the radiation oncologist may suggest a spacer to move the bowel away from the prostate. Before the treatment course begins, a temporary gel or balloon is injected into the space between the prostate and bowel.

This procedure is usually done as a day procedure under a light anaesthetic. The cost is not subsidised by Medicare. Ask your doctors what you will have to pay and the benefits for your situation.

 

Focal therapy

Focal therapy, also sometimes called ablation or focused therapy, uses high-intensity sound waves or targeted laser beams to target and destroy cancer cells.

This therapy is not a standard part of approved treatment guidelines and whether it works is unproven. Focal therapy may sometimes be offered as part of a clinical trial.

Although this is not a new therapy, there have not been enough randomised clinical trials to confirm how well focal therapy works. You can still usually have other treatments afterwards.

Androgen deprivation therapy (ADT)

Prostate cancer needs testosterone to grow. Reducing how much testosterone your body makes may slow the cancer’s growth or shrink the cancer temporarily.

Testosterone is an androgen (male sex hormone), so this treatment is called androgen deprivation therapy (ADT). It is also known as hormone therapy.

ADT for locally advanced cancer may be used after a radical prostatectomy or with radiation therapy. It may also be given to help control advanced prostate cancer. 

Types of ADT

There are different types of ADT:

  • ADT injections (most common form of ADT) – involves injecting medicine to block the production of testosterone and can help slow the cancer’s growth for years. The injections can be given by your GP or specialist. How often you have injections depends on the drug – they may be given monthly, every three months or every six months. ADT injections may also be used before, during and after radiation therapy to increase the chance of getting rid of the cancer, and are sometimes combined with chemotherapy.
  • Intermittent ADT – occasionally ADT injections are given in cycles and continue until your PSA level is low. Injections can be restarted if your PSA rises again. This is known as intermittent ADT. In some cases, this can reduce side effects. It is not suitable for everyone.
  • Anti-androgen tablets – often called hormone tablets, anti-androgen tablets may be given in combination with ADT injections.
  • Removing the testicle/s (orchidectomy) – this surgery is not a common way to lower testosterone production. If you have advanced prostate cancer, you may choose to have surgery rather than regular ADT injections or tablets. Surgery to remove both testicles is called a bilateral orchidectomy. It is possible to have a silicone prosthesis put into the scrotum to keep its shape. Removing only the inner part of the testicles (subcapsular orchidectomy) also lowers testosterone and does not need a prosthesis.

Side effects of ADT

ADT may cause side effects because of the lower levels of testosterone in the body. Side effects may include: 

  • tiredness that doesn’t go away with rest (fatigue)
  • reduced sex drive (low libido)
  • erection problems (impotence)
  • shrinking of the testicles and penis
  • loss of muscle strength
  • hot flushes and sweating
  • weight gain, especially around the middle
  • breast swelling and tenderness
  • mood swings, depression, trouble with thinking and memory
  • loss of bone density (osteoporosis) – calcium and vitamin D supplements and regular exercise help reduce this risk
  • higher risk of diabetes, high cholesterol and heart disease – more likely the longer you have ADT. Ask your doctor about these risks.

For ways to manage side effects, talk to your treatment team or visit the Prostate Cancer Foundation of Australia for more information and support. For information about erectile and other sexual health issues, visit Healthy Male.

 

Advanced prostate cancer treatment

If prostate cancer has spread (metastasised) to other parts of the body, you may have a combination of drug therapies, EBRT, ADT or chemotherapy. 

Drug therapies

Newer drug therapies may be used to treat advanced prostate cancer that has stopped responding to ADT.

These drugs (e.g. abiraterone, enzalutamide, apalutamide, darolutamide) are often daily hormone therapy tablets that can be combined with ADT to help prolong life and reduce symptoms. 

These new drugs are available through the PBS for advanced prostate cancer. Treatment usually aims to relieve symptoms or keep the cancer under control for years.

Hormone-sensitive prostate cancer may be treated with ADT alongside other treatments. Using drug therapies, chemotherapy and hormone therapies together is often called triple therapy.

Other drug therapies include drugs that target specific features of cancer cells, called targeted therapy. These drugs (e.g. olaparib) are used for cancer with gene changes (such as BRCA) linked to prostate cancer.

Radiation therapy 

You may be offered radiation therapy to slow the growth of the cancer. Radiation therapy may be given to the sites where the cancer has spread, such as the lymph nodes or bones.

You may also have radiation therapy to the prostate if you have not previously had any treatment.

Chemotherapy

Chemotherapy uses drugs to kill cancer cells or slow their growth. If the prostate cancer continues to spread despite using ADT and other drug therapies, chemotherapy may be suitable.

It may also be offered as part of initial treatment in combination with ADT.

Generally, chemotherapy is given through a drip (infusion) into a vein (intravenously). For prostate cancer, chemotherapy is usually given once every three weeks for 4–6 months and you do not need to stay overnight in hospital.

Side effects of chemotherapy may include:

  • fatigue
  • hair loss,
  • changes in blood counts
  • increasing the risk of bleeding or infections,
  • numbness or tingling in the hands or feet (peripheral neuropathy)
  • changes in nails
  • watery eyes and runny nose
  • rare side effects, such as allergic reactions or blocked tear ducts.

Transurethral resection of the prostate

This surgical procedure is used to treat problems passing urine. It helps with symptoms of more advanced prostate cancer, such as the need to pass urine more often and a slow flow of urine.

If you have localised cancer, TURP may be used before radiation therapy to relieve symptoms of urinary blockage. TURP is also used to treat benign prostate hyperplasia.

You will be given a general or spinal anaesthetic. A narrow tube-like instrument is passed through the opening of the penis and up the urethra to remove the blockage.

The surgery takes about an hour, and you will usually stay in hospital for a couple of days. Side effects may include blood in urine or problems urinating for a few days.

Bone therapies

If the prostate cancer has spread to the bones (bone metastases), your doctor may suggest treatments to manage the effect of the cancer on the bones.

Drugs can be used to prevent or minimise bone pain and reduce the risk of fractures and pressure on the spinal cord.

Radiation therapy can also be used to control bone pain, to prevent fractures or help them heal, and to treat cancer in the spine that is causing pressure on spinal nerves (spinal cord compression).

Palliative treatment

Palliative treatment helps to improve people’s quality of life by managing the symptoms of cancer without trying to cure the disease. It is about living for as long as possible in the most satisfying way you can.

As well as slowing the spread of cancer, palliative treatment can relieve pain and help manage other symptoms. Treatment may include:

  • radiation therapy to control pain if the cancer has spread to the bones
  • pain medicines (analgesics)
  • radionuclide therapy to control pain and improve quality of life. This involves swallowing or being injected with radioactive material (e.g. samarium, radium, strontium) which spreads through the body and targets cancer cells. It delivers high doses of radiation to kill cancer cells with minimal damage to normal tissues.

Palliative treatment is one aspect of palliative care, in which a team of health professionals aims to meet your physical, emotional, practical, cultural, social and spiritual needs. The team also provides support to families and carers.

“For me, the hardest part was the shock of the initial diagnosis.” Derek

Understanding Prostate Cancer

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